![](https://quantumwalrus.wordpress.com/wp-content/uploads/2016/03/clock1.jpg?w=1000&h=700&crop=1)
The Clock that we’ve all got…
According to the ‘National Institute of General Medical Sciences’, “Circadian rhythms are physical, mental and behavioural changes that follow a roughly 24-hour cycle, responding primarily to light and darkness in an organism’s environment.” But what exactly does this mean? Circadian Rhythms are commonly referred to as a ‘Body Clock’ as it regulates time-related behaviours such as sleep. However, viewing them as just a Clock doesn’t quite capture the complexity of how they work and how many processes they affect.
This ‘Clock’ is located in the hypothalamus area of the brain and contains about 20,000 nerve cells. In humans the Circadian Clock most notably regulates hormone production. These hormones are essential aspect of many behavioural and biochemical processes. Some of the most important include Melatonin, Growth hormone and Thyrotropin. Melatonin is responsible for the drowsiness associated sleep and is released at the appropriate times of day, such as sunset or leading up to an individual’s normal bedtime. Melatonin also controls the timing and release of female reproductive hormones and has antioxidant effects, possibly aiding the immune system. Recent studies have demonstrated the cardioprotective properties of Melatonin. Lower levels of this hormone may also be associated with greater risk breast and prostate cancers. Growth hormones do exactly what it says on the tin and are essential to the growth and repair of the body’s tissues whilst also helping to regulate metabolism much like Thyrotropin.
However, Chronobiology (the study of circadian rhythms), have many applications that you wouldn’t expect. One of them being an improved effectiveness in certain cancer treatments such as Cisplatin. Cisplatin works by damaging the DNA in cancer cells. Like all other body cells, they also have Circadian Rhythms that dictate the times when they repair their DNA. Now oncologists know that Cancer Cells ability to repair their DNA is at its lowest in the morning and thus time treatments accordingly.
So who needs a Rolex now, you’ve got your own watch that does way more cool stuff anyway. You’re welcome.
Daniel
Sources:
http://www.howsleepworks.com/how_circadian.html
https://www.nigms.nih.gov/Education/Pages/Factsheet_CircadianRhythms.aspx#
https://www.psychologytoday.com/basics/circadian-rhythm
http://ccb.ucsd.edu/research/sleep-behavior.html
http://www.uphs.upenn.edu/news/publications/pennmedicine/files/spring_2013_living_by_the_clock.pdf
http://umm.edu/health/medical/altmed/supplement/melatonin
http://www.webmd.com/fitness-exercise/human-growth-hormone-hgh