The Clock that we’ve all got…

According to the ‘National Institute of General Medical Sciences’, “Circadian rhythms are physical, mental and behavioural changes that follow a roughly 24-hour cycle, responding primarily to light and darkness in an organism’s environment.” But what exactly does this mean? Circadian Rhythms are commonly referred to as a ‘Body Clock’ as it regulates time-related behaviours such as sleep. However, viewing them as just a Clock doesn’t quite capture the complexity of how they work and how many processes they affect.

This ‘Clock’ is located in the hypothalamus area of the brain and contains about 20,000 nerve cells. In humans the Circadian Clock most notably regulates hormone production. These hormones are essential aspect of many behavioural and biochemical processes. Some of the most important include Melatonin, Growth hormone and Thyrotropin. Melatonin is responsible for the drowsiness associated sleep and is released at the appropriate times of day, such as sunset or leading up to an individual’s normal bedtime. Melatonin also controls the timing and release of female reproductive hormones and has antioxidant effects, possibly aiding the immune system. Recent studies have demonstrated the cardioprotective properties of Melatonin. Lower levels of this hormone may also be associated with greater risk breast and prostate cancers. Growth hormones do exactly what it says on the tin and are essential to the growth and repair of the body’s tissues whilst also helping to regulate metabolism much like Thyrotropin.

However, Chronobiology (the study of circadian rhythms), have many applications that you wouldn’t expect. One of them being an improved effectiveness in certain cancer treatments such as Cisplatin. Cisplatin works by damaging the DNA in cancer cells. Like all other body cells, they also have Circadian Rhythms that dictate the times when they repair their DNA. Now oncologists know that Cancer Cells ability to repair their DNA is at its lowest in the morning and thus time treatments accordingly.

So who needs a Rolex now, you’ve got your own watch that does way more cool stuff anyway. You’re welcome.

 

Daniel

 

Sources:

http://www.howsleepworks.com/how_circadian.html

https://www.nigms.nih.gov/Education/Pages/Factsheet_CircadianRhythms.aspx#

https://www.psychologytoday.com/basics/circadian-rhythm

http://ccb.ucsd.edu/research/sleep-behavior.html

http://www.uphs.upenn.edu/news/publications/pennmedicine/files/spring_2013_living_by_the_clock.pdf

http://umm.edu/health/medical/altmed/supplement/melatonin

http://www.webmd.com/fitness-exercise/human-growth-hormone-hgh

The Largest Flowering Plant in the World

Despite having the largest flower of any plant species on earth, Rafflesia arnoldii is nowhere near as pleasant as you might think. With an odour of rotting meat/dung and a lifecycle that is built on the back of carrion flies, this isn’t a flower that you’re mum is going to want as a ‘Mother’s day’ gift. This rootless plant is a parasite that lives in the damaged tissues of other plants and its only visible aspect is its flower. However, in its native Sumatra and Borneo it provides an income for local people through ecotourism which has raised awareness for the conservation of this vulnerable plant and the surrounding habitat. And with that I conclude this weeks edition of OOTW.

 

Daniel

Platypus – The cutest venomous creature on the market

They’re venomous, they don’t have any teeth and they lay eggs. Yes, you guessed it (probably not), this week’s OOTW is the humble platypus.

Most people have heard of this peculiar creature and it’s bizarre appearance. Some people find them as the most adorable thing to step foot on earth (just me), while others see them as an animal with a face only a mother could love. Talking of mothers, female platypus’ (I have no clue what the plural of platypus is. Platypi? Platypuses? Platypuseseseses…?), lay eggs. Yes it’s one of the few mammals that does so (the other one being the Echidna, which is also native to Australia). They were also believed to be parts of different animals that were just sewn together when they were first discovered. This isn’t very surprising considering their duck-like bill, beaver-like tail and their otter-like fur and body. However it is all of these traits that allow it to be so well-suited to it aquatic environment.

So turns out that Platypus’ are as fascinating as they are weird, and with that i conclude this week’s portion of OOTW.

Meningitis b and the vaccine that we’ve all been waiting for…

This is a disease that has gained a place at the forefront of the public’s mind. However, very few of us are aware of how the disease affects sufferers, how many people it affects and what is being done to protect those most at risk.

Meningitis is an infection of the Meninges (protective membranes), that surround the Brain and Spinal Cord. Meningitis b accounts for around 1700 cases a year of people affected by meningitis. Symptoms include: vomiting, drowsiness and convulsions/seizures among many others. 10% of survivors will develop a major complications including amputations, brain damage and hearing loss. 33% of survivors will develop less severe complications such as learning difficulties and reduced IQ. And unfortunately, around 10 young people a year will die from Meningitis b.

As you may have heard in the news recently, a new vaccine has been developed for Meningitis b. This vaccine has been particularly difficult to develop due to the external structure of the bacteria that cause the disease. Sugars on the surface of a bacteria can be used in a vaccine to allow the immune system of an individual to recognise the Bacteria in the future. However, in the case of the Bacteria that causes Meningitis b, the sugars are very similar to those that are also found on the surface of developing Brain Cells. Due to their similarity, the immune system would not identify the vaccine as anything other than a developing Brain Cell. So when an individual does come into contact with the bacteria, their immune system is unprepared. This issue has meant that other molecules on the surface of the bacteria had be found that are present in all strains. It is only recently that an effective vaccine has been produced named ‘Bexsero’ which is manufactured by GlaxoSmithKline.

However, there has been difficulty in the actual distribution of the vaccine. In 2014, the Joint Committee on Vaccination and Immunisation (the organisation that advises the government on vaccinations), recommended that children from two months old be given the vaccine, having previously advised that due to the vaccine not being cost-effective, it should not be introduced. The government then began negotiations with GlaxoSmithKline regarding the price of the vaccine in August 2014. Then in March 2015, Jeremy Hunt, the secretary of state for health, announced the agreement with the company to introduce the vaccine. It wasn’t until June of that year that the government announced the that the vaccine would be administered to all infants once they reached two months. The booster jab would then be given at four months and twelve months.

 Here at Quantum Walrus we’ll be sure to keep you all up to date with any future updates.

 

Daniel

 

Sources:

http://www.bbc.co.uk/news/health-26679492

http://news.sky.com/story/1544740/babies-to-get-new-meningitis-b-vaccine

http://www.meningitis.org/menb

http://www.nhs.uk/Conditions/Meningitis/Pages/Symptoms.aspx

http://www.nhs.uk/Conditions/vaccinations/Pages/meningitis-B-vaccine.aspx

The organism of the week is a… WALRUS!!!

Welcome to a new thing we’re doing on quantumwalrus.wordpress.com (please follow us, we’re desperate), called ‘Organism of the week’ or OOTW not to be confused with #ootd. We pick an organism that tickles our fancy that week, be it a bizarre amazonian fungus or whoopi goldberg, and write a short paragraph about it. The possibilities are endless!!

The first OOTW is, you guessed it, the elegant sea mammal that is a walrus. They’re large, in charge and we think they look hilarious. However, aside from their traditional good looks, these peculiar pinnipeds are fascinating. Did you know that they can weigh up to two tonnes with hide accounting for up to 20% of their total weight. They have whiskers just like your pet housecat, however, they probably won’t make the best pet. Unless you happen to live on an iceberg drifting through the arctic sea. Another fun fact: Those tusks never stop growing and can grow up to a metre in length. Now we hope that you can love the humble Walrus as much as we do. See you next week for another random (but amazing), organism.

 

sources:

http://www.kidsplayandcreate.com/fun-walrus-facts-for-kids/

http://www.athropolis.com/arctic-facts/fact-walrus-tusk.htm

All you need to know about the Zika virus

Over the past few weeks the media has been awash with stories regarding the Zika Virus. However, most of us don’t even know what it is and why everyone cares so much. Let’s change that.

The Zika virus is a virus belonging to the Flaviviridae family, which also includes a whole host of other diseases such as Yellow fever, Dengue fever and Hepatitis C to name but a few. Symptoms can include mild fever, skin rashes, conjunctivitis, muscle and joint pain, malaise and headache. The virus itself is transmitted by infected Aedes Mosquitoes which typically bite during daylight hours. Populations most at risk tend to be located in hot and humid areas close to the equator such as tropical Brazil, Western Africa and Pacific islands.

The Virus was first identified in Uganda in 1947 in a population of Rhesus Monkeys. First known infections of humans were discovered in 1952 in Uganda and Tanzania. In a study around that time in Uganda and Nigeria, of the 84 people involved 50 had antibodies for the virus, with everyone over the age of 40 being immune. In 1952 another study was conducted in India, which showed how a “significant number” of those involved exhibited an immune response to the virus. From these results it was concluded that Zika had been present in human populations for a long time.

Although the symptoms seem mild and are not life threatening, it is the possible complications that can be particularly dangerous. As you may have seen on the news recently, in some areas of Brazil, the number of incidences of the Zika virus has been increasing, along with incidences of babies born with microcephaly (characterised by being born with an abnormally small skull). This link may involve other factors but health professionals all over the world are still warning pregnant women to take extra precaution.

Current prevention methods are relatively straight-forward and very similar to the prevention of other diseases such as malaria that are also transmitted by mosquitoes. The ‘World Health Organisation’ has advised insect-repellent, wearing clothes that cover most of the body, keeping doors and windows closed in buildings in affected areas, sleeping under mosquito nets at night and emptying stagnant water sources where mosquitoes can breed such as flower pots and buckets. Young children, the sick, the elderly and pregnant women should take particular caution. Symptoms are usually very mild  and little to no treatment is needed for those infected, however, plenty of fluids are necessary and common medicines can be used in order to treat pain and fever. There is currently no vaccine available for the Zika virus.

I found that most of the panic involving this virus is a result of how little most people know about the disease. Hopefully we’ve changed that, just a little.

 

Daniel

 

Sources:

http://www.cdc.gov/zika/

http://www.who.int/mediacentre/factsheets/zika/en/

http://www.cdc.gov/ncbddd/birthdefects/microcephaly.html

Do You Even Understand the Gravity of the Situation? (Part 1)

Sorry about the title, it was too easy….  Anyway, by now you’ve probably figured out that this post is about gravity.  More specifically, though, it’s about why our models of it sort of don’t work. I wanted to talk about this is one post but to explain everything properly, I’m going to need more than one. This time I’ll explain where we’re up to with understanding gravity and next time I’ll move onto some problems and a couple of new theories. Enjoy 🙂

To me it seems strange to think that despite the incomprehensible complexity everything around us, the universe  is mediated by only 3 forces; the electroweak, strong nuclear and gravity. It seems stranger still that we have reasonable models of the first two, allowing some pretty impressive science to be done with their use. The strangest of all though, is how the third one, gravity, actually works. Admittedly we’ve had a pretty good approximation with general relativity (I’ll get onto how that works in a minute) for some time now. But despite this, there are still some gaping holes in the theory.

Although there are problems, it’s still worth understanding what on earth (is there a pun there? I’m not sure…) General Relativity is all about; as it’s done a pretty good job of explaining a lot of things for over 100 years now. Good job Einstein.

Unfortunately trying to understand how it works starts with a pretty big conceptual leap. This is that you have to consider the universe not as a 3 dimensional space but a 4 dimensional system of both 3 dimensions of space and one dimension of time ( the combination of the four is called space-time). If you can picture this idea in your head you’re doing better than me. Fortunately you don’t really need to picture it to get the general ideas I’m explaining. General relativity states that any object with mass will warp this space-time in such a way that objects will be attracted to it. A good way of thinking about it is by treating this space-time as a really big, tense piece of elastic. If you drop a big object onto it, like a bowling ball, the elastic will warp around the ball and the ball will sit in a dip in the elastic. Now if you were to add a smaller object like a marble, the marble will itself warp the elastic but nowhere near as much as the bowling ball, therefore it’ll roll towards the bowling ball as the ball has a much greater effect on the shape of the elastic. This is a simplified version of how gravity works due to general relativity, that an object doesn’t inherently attract something, but affects the space-time around it so that other objects will naturally move towards it.

From first observation there is only a subtle difference between the two, but this difference becomes essential when trying to understand gravitational effects on a large scale. This is because our ‘classical’ theory of gravity can’t account for a few things that we know happens, like gravitational lensing or the existence of black holes.

Like I say though, this theory isn’t perfect and there is still a bit of a way to go. Now that you’ve been pulled in (there’s definitely a pun there), I’m sure you’ll be back next time to find out why this isn’t the whole picture.

Max

Sources:

General Relativity

Gravitational Lensing

Implications of General Relativity on the Existence of Black Holes

 

 

 

 

Too much lactic acid is kind of a bad thing, but why?

Put simply, Lactic acidosis is the build-up of lactic acid in the bloodstream that is being formed quicker than it is being removed. But how does this happen, why is it a bad thing and when does it happen?

In order to survive, cells need energy in the form of a molecule known as ATP. This helpful little molecule can be broken down into its constituent parts to release energy intended for cellular processes such as protein formation and DNA replication. ATP is mostly synthesised through a process known as aerobic respiration in which oxygen and glucose molecules are essential. This process is the cells most efficient method of producing ATP. However, in certain circumstances Oxygen is available in sufficient concentrations for aerobic respiration to occur. So ATP has to be synthesised anaerobically (without oxygen), which is much less efficient and results in the production of you guessed it… LACTIC ACID!

But why is it dangerous? Enzymes are a group of proteins that are essential to the functioning of cells and carry out a diverse range of roles in the body. From digestion to replicating the DNA in each one of our cells. But in order to carry out these vital roles efficiently they need to be in the optimum conditions. This includes the pH of the area that they are surrounded by. When the pH becomes too low or too high for that particular enzyme (and it’s different for each one), the bonding that holds the enzyme together begins to break apart. So when lactic acid is released in excessive quantities, the pH of the bloodstream lowers and becomes more acidic. This can not only denature enzymes but also proteins that hold cells together, resulting in significant damage to body tissues.

However, acidosis can also be caused by diabetes (metabolic acidosis), and as a result of vomiting and diarrhoea (hyperchloremic acidosis). Metabolic acidosis can be caused by poorly managed diabetes in which a lack of insulin causes a buildup of ketones in the blood which can also result in a lower blood pH. Hyperchloremic acidosis occurs when the body suffers from a depletion in sodium bicarbonate. Sodium Bicarbonate acts as a neutraliser and prevents the pH of the body becoming too acidic. Symptoms of all of these variations of acidosis include fatigue, headaches and confusion, among others. Thankfully, swift treatment of the causes of acidosis usually results in a full recovery.

Most people associate acid with vats of bubbling, green goo in mad professors laboratories but alas, it can be found inside your very own body. So hopefully acidosis is something that you will never have to deal with but at least now you can think of yourself as your very own vat of bubbling, green goo. You are welcome.

 

Daniel

sources:

http://www.nhs.uk/ipgmedia/National/NAM/assets/Lacticacidosis.pdf

https://www.nlm.nih.gov/medlineplus/ency/article/000391.htm

https://www.nlm.nih.gov/medlineplus/ency/article/000594.htm

https://aidsinfo.nih.gov/education-materials/fact-sheets/22/68/hiv-and-lactic-acidosis

http://www.healthline.com/health/acidosis#Prevention7

Click to access Lacticacidosis.pdf

Click to access Lacticacidosis.pdf

Click to access Lacticacidosis.pdf

Click to access Lacticacidosis.pdf

The Problem Penguins Present for Physics

I’ll start by saying; I’m not making any of this up(my friends have bullied me into referencing my stuff so everything will be fully referenced in the next week or so) and it really does seem that sometimes scientists can do some pretty odd stuff. Personally I find the levitating frog thing a demonstration of this but the logic behind the title is probably weirder still. It is true though, penguins are really inconvenient.

Admittedly they aren’t the kind of penguin you’re familiar with (the bird kind) but are in fact a particular kind of quantum mechanical interaction displayed by a ‘penguin diagram’. Despite not actually having anything to do with the avian kind of penguin, the reason behind the name is still pretty cool. The upshot of it is, a scientist lost a drunken bet to include the word penguin in his next paper. He then got pretty high and decided to call the diagram of the interaction he observed a penguin diagram. It doesn’t really look like a penguin normally, it’s just that if you draw some lines a bit more curvy and put some at funny  angles it kind of looks like one. I guess this would have worked for a dog or a narwhal, but penguins it is.

penguin_diagram

This is what the diagram looks like when you want to pretend it looks like a penguin.

I mean it looks like one if you’re really trying to see it Oh scientists.  They are still pretty interesting though as they illustrate how our current understanding of physics can’t be the whole story as they are an example of something called CP violation.

The words C and P stand for (charge parity) don’t really give the whole picture but it means the physics of the standard model (the model used to describe particles and their interactions with the exception of gravity) doesn’t work if everything was backwards. If CP violation were false then  if everything in space was a mirror image of its current self, for example the writing on the screen you’d be reading from would be back to front, and every particle was swapped with its antiparticle  the physical description of these particles should remain unchanged. It would also mean that as a result of the big bang, matter and antimatter would be created in equal quantities. We know both of these things to be false, the latter by the fact we exist (if they were created in equal quantities the matter and antimatter would have annihilated and no massive particles would exist) and the former by experiment. Now this is where the penguins come in.

The interactions illustrated by penguin diagrams are one of the interactions that prove CP violation is in fact true. The maths behind it all makes my head hurt but put simply, the interaction couldn’t happen if the particles were swapped with their antiparticles (kind of what we were looking for). As I mentioned, this CP violation is a big problem because the standard model doesn’t predict it. This is because all the particles that you swap when checking if CP is violated are described by the standard model, therefore an example of CP violation is a blow for the standard model description of the universe, and as this is the best model we have to describe the universe, it still looks like there are still a few things that need ironing out before we can explain everything we know so far (most obviously being that we still need to figure out how gravity works).

I’m sure Daniel would disagree with me but I’m sure I’ve convinced you that this kind of penguin is far more interesting.

Max

Sources:

Origin of the Penguin Diagram

CP Violation

Standard Model Info

 

Sit down Children because today we’ll be learning about Diabetes – Part 2

In the last post we outlined how diabetes is characterised in individuals with the condition. This week I’m aiming to inform all our lovely readers on treatments both present and future.

Biguanide (otherwise known as Metformin), is a drug that is currently used by diabetics to reduce increases in blood glucose levels. It’s effectiveness is due to its ability to prevent the liver producing glucose (from the breakdown of glycogen), heightening the body’s sensitivity to insulin and reducing the amount of glucose absorbed from the intestines during digestion. As it is not solely broken down by the liver, this reduces the chance of lactic acidosis (We’ll talk about that one in a future post). All of these effects combined has resulted in a significant improvement in the treatment of diabetic individuals. However, Biguanide isn’t all rainbows and unicorns. It’s only effective with type-2 diabetes as it doesn’t affect the ability of an individual to produce insulin and although it improves the severity of the condition, it is by no means a cure.

Speaking of a cure, ‘Islet cell encapsulation’could be the answer. The University of California Team that conducted the initial trial implanted immature human islet cells derived from stem cells, into an individual with type-1 diabetes, via a capsule. As the cells mature, they begin producing insulin, allowing the individual to no longer be dependent of insulin injections multiple times a day. The Islet cells are protected from the immune system by the capsule, preventing them from being destroyed. But what about type-2 Diabetes?

Studies by Newcastle University has found that the development of type-2 diabetes is linked with the amount of fat stored in the Pancreas and Liver. However, there is no standard measure of when someone will develop type-2 diabetes from this process as individuals have varying tolerances of how much fat they can store in these areas. That said, according to the study, ‘ people who have had type 2 diabetes for 4 years or less, major weight loss returns insulin secretion to normal.’

All of these treatments have advantages and disadvantages regarding their effectiveness but due to the complexity of Diabetes as a condition that has many variations, a cure has not yet been discovered. But with research teams across the globe working tirelessly to change that fact, I have no doubt that sometime in the future, they will.

Daniel

Sources:

http://www.diabetes.co.uk/Diabetes-Cure.html#t2a

http://www.diabetes.co.uk/news/2014/oct/islet-cell-encapsulation-system-implanted-into-person-
with-type-1-diabetes-90129387.html

https://www.diabetesresearch.org/cure-research

http://www.diabetesresearch.org/cell-supply

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094530

https://www.diabetes.org.uk/Guide-to-diabetes/What-is-diabetes/Diabetes-treatments/

https://www.diabetes.org.uk/Guide-to-diabetes/What-is-diabetes/Diabetes-treatments/Biguanide-

/

http://www.ncbi.nlm.nih.gov/pubmed/7862618

http://www.diabetes.co.uk/diabetes-medication/biguanides.html

http://care.diabetesjournals.org/content/35/2/446.full

http://www.ncl.ac.uk/magres/research/diabetes/reversal.htm